It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
Voluntary recalls were issued for specific lots of two opioid pain relievers and one medication for tension headaches. The affected drugs include:
Endocet (oxycodone/acetaminophen), 10/325 mg
Hydrocodone/acetaminophen, 7.5/500 mg
Butalbital/acetaminophen/caffeine, 50/325/40 mg
Endocet (oxycodone/acetaminophen) Endo Pharmaceuticals issued the nationwide Endocet recall because a bottle from each of two lots was found to contain some 10/650 mg tablets, which is twice the dosage of acetaminophen on the label. Because of this, consumers may take more than the intended acetaminophen dose. Possible Dangers: Unintentional administration of tablets with increased acetaminophen content may result in liver toxicity, especially in patients on other acetaminophen containing medications, patients with liver dysfunction, or people who consume more than 3 alcoholic beverages a day. Lots: The two lots affected are Lot # 402415NV and Lot # 402426NV. They were distri...
Saccharin, aspartame, sucralose. Which sugar substitute is best?
It used to be that we didn't have much choice. When we went to the supermarket, we could find various formulations of saccharin, and then aspartame and more recently, sucralose.
Stevia, which comes from a South American plant, has been used as a sweetener for years in other countries, including Japan, but couldn't be used in the United States except as a "supplement," sold along with vitamins instead of in the sugar aisle at the grocery store.
I've described all these sugars in more detail in my book The First Year Type 2 Diabetes, and I won't repeat that information. Instead I'll describe a few of the newer sweeteners.
Recently, there seems to be a flood of new products on the sugar shelves. This is partly because the FDA has finally approved some stevia products for use as sweeteners, and some of the "big boys" in the food manufacturing world have jumped on the stevia bandwagon.
Two big boys on the sugar shelf are prod...
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