Thursday, October 23, 2014

Tuesday, June 16, 2009 Mombat39, Community Member, asks

Q: Is it safe to take Prilosec and Zantac at the same time?

My son is in the military and has been prescribed Zantac, Prilosec and Reglan simultaneously.  I'm concerned about the combined affect of Prilosec and Zantac.  Is this safe?

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Answers (2)
Stephanie, Health Guide
6/16/09 7:33pm

You will not be able to find anything that says it's safe but I do know that it is often done. I work with young children and I've even seen it done with them. They have different mechanisms of action and doctors do use them together. While there is nothing to support using them together, luckily there is also nothing saying it's harmful (at least not yet).



Jan Gambino, Health Guide
6/17/09 8:41am


It is important to take the Prilosec on an empty stomach 30 minutes before a meal. In addition, the Zantac needs to be given at a separate time than the Zantac. While both medications reduce acid, they work in different ways. Sometimes the doctor recommends the Prilosec (PPI) in the am and the Zantac at night.

Reglan has some new black box warnings from the FDA so read the info on this site and my blog with the newest information.


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By Mombat39, Community Member— Last Modified: 01/20/13, First Published: 06/16/09