I have been taking PPI's every day for 9 years. I slowly developed an anxiet disorder and was diagnosed with GAD (generalized anxiety disorder) 3 years ago. This also lead to a major depressive episode. I was 48 yrs old when this happened and had never had anxiety or depression in my life, nor did I have any family history of either. There have been several (unpopular) studies that demonstrate the long term effects of reduced hydrochloric acid in the stomic - which is exactly what PPI's do. Without sufficent acid, your body cannot extract specific vitamins and minerals from the foods you eat, even if you eat healthy. According to studies I've read, these include B vitiamins, calicum and magnesium. I am only a partial responder to the benzo's and anti-depressents I've been taking - and I've tried quite a few. Diagnosing deficenies is not that straightforward. I have been feeling better after taking magnesium (topical). Good luck!