I was a long-time sufferer with heartburn and was diagnosed with Barrett's esophagus a few years ago. While my symptoms have been under control, I worry about esophageal cancer. Do any drugs prevent the development of esophageal cancer in patients with Barrett's esophagus?
It has long been felt that medications could not prevent the progression of Barrett's esophagus to cancer. Initial reports of a current study in progress in the United Kingdom is looking at whether treatment with aspirin and Nexium can stop Barrett's from progressing to cancer. The study has been ongoing since 2005, and while it is unclear as of yet as to whether the drug combination is efficacious, what has come out is that the use of aspirin in patients with Barrett's esophagus is safe and well tolerated. While some patients have experienced increased incidences of heartburn, requiring an increased dosage of Nexium, few have dropped out of the study. This was an important step, as there were fea...
Definition Esophageal cancer is a cancerous (malignant) tumor of the esophagus, the muscular tube that moves food from the mouth to the stomach. See also: Barrett's esophagus Alternative Names Cancer - esophagus Causes, incidence, and risk factors Esophageal cancer is not very common in the United States. It occurs most often in men over 50 years old. Two main types of esophageal cancer exist: squamous cell carcinoma and adenocarcinoma. These two types look different from each other under the microscope. Squamous cell esophageal cancer is linked to smoking and alcohol consumption . Barrett's esophagus , a complication of gastroesophageal reflux disease (GERD), increases the risk for adenocarcinoma of the esophagus. This is the more common type of esophageal cancer. Other risk factors for adenocarcinoma of the esophagus include: Male gender Obesity Smoking
Hairy leukoplakia; Smoker's keratosis
The goal of treatment is to get rid of the lesion. Removing the source of irritation is important and may cause the lesion to disappear.
Treat dental causes such as rough teeth, irregular denture surface, or fillings as soon as possible.
Stop smoking or using other tobacco products.
Do not drink alcohol.
You may need surgery to remove the lesion. The lesion is usually removed in your health care provider's office using local anesthesia.
Leukoplakia on the vulva is treated in the same way as oral lesions.
Leukoplakia is usually harmless. Lesions often clear up in a few weeks or months after the source of irritation is removed.
Oral hairy leukoplakia is often a sign of HIV infection and an increased likelihood of developing AIDS , but it is not harmful by itself.
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