Nexium (esomeprazole) is one of a number of Proton Pump Inhibitor drugs (PPIs) that work by blocking some of the cells that produce hydrochloric acid in the stomach.
They are not an instant relief drug like an antacid (eg Tums) or an alginate (eg Gaviscon) and their effects slowly build up. You should start noticing the effect within a few days but it may take longer to be really noticeable.
If you have a particular urgent problem like gastritis, ulcers or esophagitis, you will probably be on an initial high dose (40mg) for a few weeks for the problem to be sorted and the dosage may then be reduced to a maintenance level (20mg).
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