claire kee,   That's a tough question. There are pluses and minuses to both drugs.   Pantoprazole is classified as a proton pump inhibitor. It works by blocking acid production in the stomach. PPI's have been shown to be the most effective medications for treating acid reflux. However, there are associated side effects - such as bacteria overgrowth in the intestine.  However, studies have shown Pantoprazole to be relatively safe is both short term and long term trials. (read more on the drug here.)   However, Zantac is an H2 Histamine blocker. This class of drugs also works to block or prevent the production of stomach acid. As you know, there are also associated side effects. (read more about Zantac here.)   Certain medications are more effective for different people. You should discuss with your doctor the different options and decide which is right for you, and only take medications as often as your doctor has prescribed.