Hello, I came across your question. I don't know if Nexium causes brittle bones but I've read that Nexium, Prevacid and Prilosec (which my son was on) while these drugs may help treat symptoms in the short-term (4 to 8 weeks, maximum), long-term use can cause the body to produce an extra amount of the hormone called gastrin. Gastrin is the substance that tells your stomach to make more acid. There are gastrin receptors on the esophageal, pancreatic, and gastric cancer cells, and over-production of gastrin can cause these cancer cells to grow too large, thus greatly increasing the risk of cancer in these areas. This is why I recently got my son off his med. Whats the point of taking these acid reflux medications if they produce more acid and that is why I'm looking for natural remedies. Try looking on www.pennherb.com or www.Vitaminshoppe.com.