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Samar, Thanks for your question. Nexium (generic name: esomeprazole) is not known to cause low calcium levels. You said that you are taking calcium and vitamin D daily - that's a good start to preventing osteoporosis. It's important to make sure that you're getting enough calcium. For women over the age of 50, it's recommended that you get 1200 mg of calcium daily. You can get more information about Nexium here. Best of luck, Casey
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