Q: Does Nexium have a negative effect when taken with Plavix?
Research came out last year that suggests that taking Plavix and a Proton Pump Inhibitor such as Nexium can increase the risk of a "cardiac event" such as a heart attack. You can find the link to the abstract here:
http://circ.ahajournals.org/cgi/content/meeting_abstract/118/18_MeetingAbstracts/S_815
The thought is that the PPIs inhibit the activation of an enzyme that is necessary for the Plavix to work.
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