Zantac (also known as ranitidine) is used to treat peptic ulcers and GERD. It works by blocking the activity of a group of specialized cells in the stomach lining (histamine-2 receptors) that are involved in the production of stomach acid. Tagamet (also known as cimetidine), Axid (also known as nizatidine) and Pepcid(also known as famotidine) are members of the same group of drugs known as H-2 blockers. There are two concerns with alcohol and the use of these drugs. There is some evidence that Zantac and the other H-2 blockers may cause an increase in the blood levels of alcohol. This would increase the effect of the alcohol.
Perhaps the more important concern is the effect of alcohol on the stomach. The vast majority of people taking H-2 blockers are taking them for GERD. We know that GERD is the result of stomach contents getting up into the esophagus because of an improperly functioning valve (called the lower esophageal sphincter, or LES). The LES is too relaxed in people with GERD. That opens the passageway between the stomach and esophagus and allows stomach contents to get into the unprotected esophagus, causing what most people call heartburn. Some foods, including alcohol, cause the junction to relax. That is why most experts advise people against drinking alcohol if they have GERD. Sothere is a problem with drinking alcohol if you are taking Zantac for GERD. Alcohol can also cause an increase the amount of acid produced in the stomach. The increase in stomach acid can worsen the problem with GERD as well as limit the healing of stomach ulcers.
