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Hi, just wanted to mention that our situations are very similar.  I concentrate MUCH better on the Adderall, however, go into a slump when not on it.  There is a fine line between bipolar/ADHD.  I am convinced, given the inadequancies I have always felt (and masked well) and my accomplishments (rn, then bachelors), I have masked things well.  I also have had tremendous struggles related to relationships.   I feel we build up a tolerance to medications at some point.  I had been on Wellbutrin w/Adderal 40 daily.  I recently quit the Wellbutrin and started on Prozac.  Prozac is not just for depression.  It helps with repeated negative thoughts (similar to OCD), feeling need for repetiotion, anxiety and constant worrying.  Taking the prozac, coupled with the Adderall has made a difference.    Finally, and most importantly.  I listed to a show briefly by Joyce Meyer.  She is, YES, an evangelistic lecturer.  She quoted many scriptures and also focused was focusing on her irritation over things related to her husband, job, etc.  Her bottom line was GET OVER YOURSELF!  This really hit me.  Yes, we may need medication.  Yet, we have a choice how much negativism and how much we want to KEEP PONDERING these things, that we do.  Perhaps you need a change in meds.  Pray, do it, and then GO ON.  Start to concentrate on what you need to do for YOURSELF to improve yourself.  Do this with the attitude that the more you improve yourself, the more valuable you will become to others.  Ask ALWAYS for God's help.  If you don't believe, I urge you to read the book of John.  Phil 4:13.  You will feel best about yourself when you give (what you have ... not your perfect self) to others.    Yes, I am on meds;  yes I am sick of asking questions, seeking MDs and feeling as if "I am the only one going through this" ... in a way I am sick of being my own worst enemy and causing myself to feel so negative.  Recognize also, that there are principalities of darkness, and that God did NOT give you a spirit of weakness, but of a strong, sound mind.  If you feel inadequate and talk negativism to yourself, WHO do you think is helping to create this within you???  If you believe in God and His word, you MUST believe then, that the enemy, Satan is real and he comes to kill, rob and destroy! Read your bible, learn the truth and arm yourself appropriately.    I am not saying we do not need medications.  But we need to do our part mentally and spiritually as given on the directions of the bottle for the meds and the BIBLE for our intructions on life!!   Good luck my friend.  I know you will be find.  You have the power of a sound mind and the ability to use it.  I pray for you that the Lord is with you and pray against all evil spirits that come against you and your mind at this time and rebuke them in the name of Jesus.  Remember, where two or more are gathered and pray, God hears and answers.  Satan LOVES to get into our heads, yet hates when we use the precious name of Jesus to rebuke him and his powerful enemies out of our lives.  He has no choice but to leave.  Pray that with me, continue to see your MD, concentrate on others and only what is good for your life and you will SEE a difference quickly.    I understand, care and pray for you.  Bonjo999