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It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
Generic Name: OXYCODONE/ACETAMINOPHEN - ORAL Pronounced: (OX-i-KOE-done/a-SEET-a-MIN-oh-fen) Oxycodone-Acetaminophen Oral Uses
This combination medication is used to help relieve
moderate to severe pain. It contains a narcotic pain reliever (oxycodone) and a
non-narcotic pain reliever (acetaminophen). Oxycodone works in the brain to
change how your body feels and responds to pain. Acetaminophen can also reduce
How To Use Oxycodone-Acetaminophen Oral
See also Warning section.
Take this medication by mouth as directed by your doctor.
You may take this drug with or without food. If you have nausea, it may help to
take this drug with food. Ask your doctor or pharmacist about other ways to
decrease nausea (such as lying down for 1 to 2 hours with as little head
movement as possible).
If you are using a liquid form of this medication, use a
medication measuring device to carefully measure the prescribed dose. Do not
use a ho...
Alternative Names Overdose - hydrocodone; Overdose - oxycodone; Vicodin overdose; Percocet overdose; Percodan overdose; MSContin overdose; OxyContin overdose Before Calling Emergency Determine the following information: The patient's age, weight, and condition Name of product (as well as the ingredients and strength if known) The time it was swallowed The amount swallowed If the medication was prescribed for the patient Poison Control, or a local emergency number The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions. This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. Take the container with you to...
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