Judy,   It sounds like your physicians are unfamiliar with neurobiology, neuroendocrinology,. and the possible effect that Vyvanse might be having on you.   I'm not a physician, but I've heard many (many!) stories of encounters with physicians who have difficulty assessing the "big picture" -- that is, hormones, thyroid, medication side effects, etc.  It's easy to understand; this is complicated stuff!   The fact is, Vyvanse is an amphetamine-based medication. And while some people find it greatly enhances their lives, it only makes sense that a medication that can create great positive changes could create other side effects.   There are many possibilities. For example, if your physician is not addressing any co-existing "serotonin-related" issues (such as anxiety or depression), the stimulant alone could be backsuppressing serotonin; the symptoms you describe are not out of line with that phenomenon.    It could also be that your body is not getting enough (or utilizing existing) amino acids -- the precursors to neurotransmitters.   And it's also possible that some other health issue, unrelated to the Vyvanse, has cropped up.   Good luck sorting it out.   Gina Pera, author Is It You, Me, or Adult A.D.D.? http://www.ADHDRollerCoaster.org