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Heather   Tiredness can be a side effect of Depakote. It may disappear as your body adjusts to the medication, however, I would still contact your doctor and just let her know how you are feeling. She would be best able to determine if your dosage should be adjusted or if you should stay on to see if you begin to feel better. Either way, it is important to let your doctor know the side effects you are experiencing.   Eileen
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