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Thank you for your question and welcome to ADHDCentral.com.   I am not a medical professional, however, from the information I could find you should be cautious taking Topamax if you have liver disease and should tell your doctor before beginning Topamax. This is because the liver aids in clearing Topamax from your system.   If you have any questions or concerns about your medications, you should talk with your doctor.   Eileen
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