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Hi adhddepressom,   You do have your hands full and my heart goes out to you and your daughter. It's no fun for her to feel so awful and it's got to be hard on you, not knowing where to turn. I would wonder about whether her behaviors have gotten worse since being on any of those medicines or...if she's been this way before meds and they simply aren't helping her symptoms. That would be my first question, because as you know, it's hard to figure out what is causing what.   Stimulants can cause irritability, but so can a lack of sleep! The aggressive behavior is concerning. Is her formal diagnosis ADHD and depression? Has there been any suggestion of a possible mood disorder?   I don't know what type of doctor is treating your daughter, but if it isn't a child psychiatrist, I would immediately begin researching and finding one that has expertise in the types of problems your daughter is experiencing. You can ask her pediatrician for a referral. You can also find one by contacting your local CHADD chapter at www.chadd.org or calling them at 800-233-4050 for names of local doctors.   Also, try calling your local Children's Hospital and ask the psychiatry department for names of psychiatrists who are familiar with ADHD + depression.   In the meantime, I would also get involved with the CHADD chapter so YOU can get the support you need.   Lastly, I would highly recommend counseling for your daughter to help her with all of this. Find someone who will also engage you so that you know how you can also help her at home.   Hope this helps!Terry