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Tuesday, November 24, 2009
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Vyvanse Oral

Drug Interactions


Generic Name: LISDEXAMFETAMINE - ORAL
Pronounced: (lis-DEX-am-FET-a-meen)

Vyvanse Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting lisdexamfetamine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

  • alpha blockers (e.g., prazosin)
  • antipsychotics (e.g., chlorpromazine, haloperidol)
  • certain antidepressants (e.g., tricyclics such as nortriptyline/imipramine, SSRIs such as fluoxetine/paroxetine, duloxetine, venlafaxine)
  • certain anti-seizure drugs (ethosuximide, phenytoin, phenobarbital)
  • certain pain medications (meperidine, propoxyphene)
  • certain street drugs (e.g., LSD, MDMA/"ecstasy")
  • lithium
  • medication for high blood pressure (e.g., beta blockers such as atenolol/metoprolol, clonidine, guanethidine, methyldopa)
  • medications that affect the acid level of the urine (e.g., sodium bicarbonate, acetazolamide)
  • other stimulants (e.g., methylphenidate)
  • sedatives (e.g., lorazepam, certain antihistamines such as diphenhydramine)
  • veratrum alkaloids (e.g., cevadine, veratridine)


Also report the use of drugs that might increase seizure risk when combined with this medication such as isoniazid (INH), phenothiazines (e.g., thioridazine), or theophylline, among others. Consult your doctor or pharmacist for details.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Ask your pharmacist about using these products safely.

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