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Vyvanse Oral Medication Interactions


IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate or effective for you. Consult your healthcare professional before using this drug.

Generic Name: LISDEXAMFETAMINE - ORAL
Pronounced: (lis-DEX-am-FET-a-meen)

Vyvanse Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting lisdexamfetamine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

  • alpha blockers (e.g., prazosin)
  • antipsychotics (e.g., chlorpromazine, haloperidol)
  • certain antidepressants (e.g., tricyclics such as nortriptyline/imipramine, SSRIs such as fluoxetine/paroxetine, duloxetine, venlafaxine)
  • certain anti-seizure drugs (ethosuximide, phenytoin, phenobarbital)
  • certain pain medications (meperidine, propoxyphene)
  • certain street drugs (e.g., LSD, MDMA/"ecstasy")
  • lithium
  • medication for high blood pressure (e.g., beta blockers such as atenolol/metoprolol, clonidine, guanethidine, methyldopa)
  • medications that affect the acid level of the urine (e.g., sodium bicarbonate, acetazolamide)
  • other stimulants (e.g., methylphenidate)
  • sedatives (e.g., lorazepam, certain antihistamines such as diphenhydramine)
  • veratrum alkaloids (e.g., cevadine, veratridine)

Also report the use of drugs that might increase seizure risk when combined with this medication such as isoniazid (INH), phenothiazines (e.g., thioridazine), or theophylline, among others. Consult your doctor or pharmacist for details.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Ask your pharmacist about using these products safely.

Avoid drinking large amounts of beverages containing caffeine (e.g., coffee, tea, colas) or eating large amounts of chocolate. Caffeine can increase the side effects of this medication.

This medication may interfere with certain laboratory tests (including blood and urine steroid levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Information last revised August 2011 Copyright(c) 2011 First DataBank, Inc.