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http://novasinuscenter.wordpress.com/2010/03/04/biofilms-and-chronic-sinus-pain/
Dr Karen
Nova Sinus Center
Sinus Treatment Specialist
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Yes, I think biofilms are a key reason why chronic sinus pain and pressure are so hard to treat with antibiotics. They simply arent effective: http://www.novasinuscenter.com/Antibiotics-Not-Effective_ep_38-1.html
Certain nasal sprays can be worse: Nasal sprays create a vicious cycle in sinus infections: http://wp.me/pmQ8F-1R