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New HFA Reliever Inhalers for Asthma- Things You Should Know

James Thompson, MD
James Thompson, MD
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Board Certified Allergist and Asthma Specialist

I am a board certified allergist and belong to a large single...

James Thompson, MD

Saturday, February 02, 2008
View All of James Thompson, MD's Posts
  By now many of you are aware of the arrival of HFA inhalers that represent the new environmental friendly carriers for aerosol inhalers. Three new brands of albuterol are currently available as Proair HFA, Proventil HFA, and Ventolin HFA.   Xopenex HFA is a purified form of albuterol t...
  1. thank you
    Sloane Miller
    Tuesday, February 12, 2008 at 12:55 PM
    this is really helpful information, thank you!
    Reply
  2. HFA inhalers
    stephanie parker
    Monday, September 15, 2008 at 09:28 PM

    HFA inhalers don't work. I know, I've tried them. You point out they need to be primed 4 times first. I assume that means 4 puffs into the air. So they cost more to begin with and contained 200 doses divided by 5 = 40 doses per container. I'm amazed you report this with a straight face.

    Reply
    re: HFA inhalers
    James Thompson, MD
    Tuesday, September 16, 2008 at 08:30 PM

    Hi Ms. Parker,

     

    I advise you to discuss your concerns with your prescribing doctor. Other people share in your frustration with the new inhalers. Some HFA inhalers have different specifications regarding priming doses (some require fewer than 4 priming sprays and longer intervals between priming). The package insert gives the details. Proventil HFA requires 3 priming sprays initially, and if not used in 2 weeks, for example.

     

    I think your calculation of 40 doses/canister is way off. Most people do not use 160 doses for priming. I don't know why you divided the total number of doses by five.

     

    I try to report the facts along with some opinion. There are many people that so rarely need reliever inhaler, the new formulations don't matter to them. Their controller medications (some of which are also HFA based) diminish the need for rescue medication. That's the goal I strive for, in my patients.

     

    Again, discuss your concerns with your doctor. Perhaps a different brand of HFA inhaler may work better. Maxaire Autohaler has another year before the company has to convert to HFA. I have switched some of my unhappy patients (those unhappy with HFA relievers)

    to Maxair, which still contains the old CFC propellant. Maxair must be primed more often but the canisters have 400 doses in them. Unfortunately it may cost more, based on insurance coverage.

     

     

    Good Luck,

     

    J. Thompson, MD

    Reply
    re: HFA inhalers
    jen allen
    Sunday, January 25, 2009 at 07:23 PM

    the new hfa inhalers are far inferior to the old cfc inhalers. please visit our website to learn the facts and to sign our petition to bring back the old cfc inhalers. www.savecfcinhalers.org

     

    jen lee

    the national campaign to save cfc inhalers

    Reply
  3. Untitled Comment
    justin
    Monday, February 09, 2009 at 03:09 AM

    I'm a 35 yr old male who was diagnosed whith athletic induced asthma in my early 20's. I'm concerned about my asthma lately due to the fact that it has become progressively worse in the last year. I have used Flovent, albuterol, and Singulair 10mg to help control my asthma throughout the yrs, but I mostly relied on my albuterol to get me through the day (once or twice a day). When my asthma would flair up I would start using my Singulair until I thought it was under control (maybe a week or so). I never really used the Flovent until this year when my asthma flaired up, and I could not control it with the albuterol and Singulair. I found out how much Flovent really helps and reduces the amount of albuterol that I need.I've been laid off and now I don't have insurance and it's to expensive for me to buy the medication so I only use albuterol and Singulair. Last month I went to get a refill on my meds Singulair and albuterol before I ran out, but I was given the new Proventil HFA albuterol inhaler instead of the CFC albuterol inhaler (Armstrong). In using the new inhaler my asthma seemed to get progressively worse over a few weeks of use to the point I was using it every 2-3 hours. I was still using the Singulair. That said, I went back to my old inhaler and continued to use the Singulair, as well as using some supplements and tea. Over the next 10 days or so, my asthma receded and I had stopped the use of my albuterol inhaler for a couple of days. I then went to my Pharmacist and asked her if I could have been allergic to the Proventil HFA. She said more than likely no, but she checked the ingredients to see if there were any differences between the two albuterols. No differences. She called my Dr. to get a different brand...Proair which I have used a couple of other times. Now my asthma has flaired up again, with no surprise after not using an inhaler. I have begun to use the Proair HFA and again it seems that I'm begining to use it more often than I would have with the CFC inhaler. I am still using the Singulair and supplements. Is it possible that the HFA gas hydroflouroalkane-134a is triggering the flair up and is there an alternitive to the HFA inhalers?

    Reply
    re: Untitled Comment
    James Thompson, MD
    Monday, February 09, 2009 at 03:27 PM

    Hi Justin,

     

    Unfortunately your experience with the new inhalers that are HFA based is not unique. Some of my patients remain convinced that these new reliever inhalers are inferior to the old CFC types. When I hear of such complaints I spend several minutes detailing the importance of priming, cleaning and practicing good inhaler technique. If you are doing all these things correctly and consistently but still having problems, adjustments in medications should be considered.

     

    Suggestions:

     

    Consult your asthma care provider first. There is one brand of CFC inhaler for relief of asthma symptoms still available. Maxair Autohaler is currently not available as HFA. As far as other alternatives to the HFA types, none are available with albuterol as the chief ingredient. Xopenex HFA is a more purified form of albuterol that perhaps may be more effective (but may be more costly).

     

    If you were under my care I would reassess your level of asthma control on Singulair alone (Pulmonary Function Test). If appropriate, I would have you restart an inhaled steroid that is comparable or less costly than Singulair, and after reviewing your response, consider stopping the Singulair (Inhaled steroids are the definitive and preferred controller for treatment of persistent asthma). I would provide you with as many samples as I could to get you started. Nothing wrong with asking your doctor about samples.

     

    I will be posting an article about how to save money on asthma medications soon so stay tuned (www.MyAsthmaCentral.com).

     

    Final Words:

     

    Consult your doctor about your concerns about the inhalers as well as your finances.

     

    Good Luck!

     

    J. Thompson, MD

    Reply
    re: re: Untitled Comment
    justin
    Tuesday, February 10, 2009 at 01:43 AM

    Thank you for your time and consideration to evaluate my case. Your advice is much appreciated and I look forward to reading your article. I will consult with my Dr. about your suggestions and hopefully we can find somthing that works for me.

     

    Thanks,

    Justin

    Reply
  4. Albuterol CFC/HFA inhalers
    Warren B
    Friday, April 17, 2009 at 01:53 PM

    I still don't understand why the necessity to change from the CFC to the HFA propellant. There couldn't have been enough CFC in an inhaler to make any difference to the environment. Another case of the environmentalists having their way without any science to back it up? My new HFA inhaler cost three times as much and my perception is that I'm not getting as much therapeutic benefit from it.

    Reply
    re: Albuterol CFC/HFA inhalers
    James Thompson, MD
    Saturday, April 18, 2009 at 12:30 AM

    Hi Warren,

     

    I think there are many people that share your concerns and agree with your comments. There are millions of cars and refrigerator units still generating CFCs (from coolants used in the radiators and freezing components) that are obviously more of a factor than aerosol medications.

     

    I think world leaders in environmental science are on the right track but they are starting with really small beans. Guess you have to start somewhere, and medications were an easy target.

     

    Many people feel the new hfa inhalers don't have the same impact as the cfc containing ones. Certainly the force, temperature and other characteristics of the spray are different. The dose of the active drug (albuterol) in each spray is the same.

     

    The majority of my patients don't complain about the response to the HFA reliever inhalers because it is really de-emphasized when asthma is well controlled (meaning it is rarely needed). My major goal is to control the asthma such that albuterol types of inhalers are seldom required.

     

    No doubt the cost difference, not having a generic alternative, is a royal pain for most. Hopefully the brands will compete with each other enough to drive some of the cost down. But this won't be happening soon, and don't expect to see a new generic form for several years. I know, just what you wanted to hear, sorry.

     

    Best Wishes,

     

    J. Thompson, MD

     

    Reply
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