According to information I found at Levaquin.com, this medicine does not interact negatively with antihistamines. So it seems likely that you could safely take one. Common over the counter antihistamines include Claritin and Zyrtec. There may be others such as Benadryl and Chlor-tri-meton, but they are more likely to cause drowsiness and other side effects than the first two I mention. There are also antihistamine nasal sprays available, which you might want to consider. They work only in the nose and are unlikely to get into your bloodstream in any quantity that could interact with the Levaquin anyway.

However, I want to encourage you to talk with your personal physician and possibly your pharmacist about this. They are the ones who will best know your condition and your medication regime. Levaquin may cause a number of risky and severe side effects on its own, so it's not a good idea to add other medicines without talking with an expert first.

To your health,

Kathi