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No, do not do that!   First, make sure that you have not come in contact with any clothing or anything else that may have poison oak on it. The oil in the plant's leaves that causes the itching and blistering can remain on clothes and fabric for a long time. If you come in contact with the oil again, it can cause new blisters. Make sure you wash the clothes (with soap) you were wearing when you got poison oak. If you had them in a laundry bag, wash that too. If you have any pets that were also exposed to the poison oak, give the pet a bath.   With the lotion, read all the information that came with the calamine lotion. Follow all directions on the product package, or use as directed by your doctor. Shake the bottle well and then apply the medication with a cotton pad, and allow the medication to dry on the skin. If you are uncertain about any of the information, consult your doctor or pharmacist.   If you still don't get relief, or the rash and blisters seems to get worse or spread, then contact your doctor right away.