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Just read a piece on cottonwood allergy from whatcom county.  It said that when the cottonwood fluff is flying, and people become allergic, what they're really allergic to is invisible grass pollen which peaks at the same time, and not the cottonwood fluff. Cottonwood pollen is produced much earlier, long before the fluff starts flying.  I start sneezing like crazy, too, when the cottonwoods start flying, and always thought that was my allergy.  I take cetirizine (generic zyrtec) and it works, doesn't make me sleepy