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Immunotherapy given by injection (allergy shots) is well-tested and quite safe when given by a qualified practitioner, namely an allergist. An allergist is a doctor who specializes in the diagnosis and treatment of allergies. There is always some risk of an allergic reaction or even anaphylaxis following a shot, but the risks are generally low. And since your doctor will require that you remain in the office for 30 to 60 minutes following each shot, you'll be able to get quick treatment, on the off chance it is needed.   There is another form of immunotherapy called allergy drops, which are usually placed under the tongue. Though they are not yet officially approved for use in the US (though they are available), allergy drops have been well tested in Europe, particularly for tree pollen and are considered effective.   You don't say which type of immunotherapy you are beginning or who will be administering it. But, as long as you're going to a board-certified allergist, the risks should be low. As to effectiveness, it's always hard to predict with certainty how anyone will respond to a specific treatment because each body is different. But immunotherapy in general is considered to be a highly effective treatment for allergies.   To your health, Kathi