Thank you for asking this question. As has previously been mentioned you can grind up some types of medication. However this can affect the absorption rate of the drug or cause side effects such as gastric problems so medical advice is required. Some types of medication do come in syrup form so his prescription may need to be renewed.   There is also an issue of human rights that all good care homes will be aware of. To give a drug against someone's wishes is of concern. When this occurs a doctor must be involved in the decision making process to advise and give permission for care home staff to administer the drug. This safeguards patients, staff and relatives.  A doctor will also be able to offer advice on any legal issues if it is necessary.   I know it sounds complicated, especially when we all know that most medication is very important and gives someone with dementia a better quality of life, however...   Christine