Hi, Mikepal,   I just had the opportunity to hear Dr. David Snowdon (the researcher who has done one of the most definitive studies about Alzheimer's) speak. He said the best thing to do is exercise (particularly cardio). In fact, he said if it was a choice between doing a crossword every day and exercising, opt for the exercise.   The other things that Carol mentioned also have been shown to be helpful by research - controlling stress, trying new things, building a community of strong relationships, and diet (especially by following a Mediterranean diet).   Hope this helps! Keep us posted!   Dorian