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Sunday, September 14, 2008 chris, Community Member, asks

Q: can i take 50mg of xanax and be safe

Can I take 50mg of Xanax and still be safe? Does anyone know what the maximum dosage is?

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Answers (7)
Dr. Diana L Walcutt, Health Guide
9/14/08 8:23pm

Hi Chris:

Have you spoken with your physician about this? Recommended dose is 0.25 to 0.5 mg, and you are asking if you can take 100 times the recommended dose. If you are treating panic disorder, then treatment of some panic disorder patients has required the use of Xanax at doses greater than 4 mg daily. When they were doing research they were testing up to 10 mg a day, but that was very rare. You are asking about 5 times the highest doses tried in research in very controlled situations. You can read more about Xanax here.

You really need to call your doctor about this. Benzodiazepines are dangerous, very addictive, and should be respected.


Best of luck,

Dr. Diana Walcutt


*Dr. Walcutt is a Psychologist, not a Psychiatrist. Psychiatrists prescribe medications. Psychologists study them, but most Psychologists are not authorized to prescribe meds or give you specific advice about them. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.

9/15/08 9:44pm

Chris - Dr. Walcutt gave you all the important information and hopefully you understand that the answer is NO! However, please check your prescription bottle because it may actually read .50mg and not 50mg. There's a really big difference and .50 is a fairly typical dose. If you have any doubts always consult your physician and/or pharmacist!


Rick Wirtz


Rick Wirtz is a Psychologist, not a Psychiatrist. Although the majority of Psychologists are not authorized to prescribe medications or give you specific advice about them, they typically have experience working with patients who take a variety of medications. The response above is not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only and primarily to aid you in having an informed discussion with your own physician.

10/ 6/09 10:44pm

50mg is NOT a dosage any doc would or could write. The truth is there are heavy users of illicit Klonipin that I have seen down close to that dosage over a day but they were on IV Speed runs. If you are on anything close to 10mg of Klonipin you are pushing the limit on the body's ability to detox. It takes approx. 15mg of Valium to = 1mg of Klon (that is the EU standard and is used in many states as a guide to detox). In Texas the TXPA uses 10mg Valium (diazepam)=1mg Klonipin (clonazepam). The point is that if you look at valium, (See equivalency tables on Roche site) you are taking a real risk of accidental OD by ingesting foods, drugs, or herbal suppliments (sp? sorry) that will inhibit one of the pathways to clear the benzo's and the metabolites. You will risk eating a ham salad sandwich and not waking up later. By the way, body weight, but more importantly the amount of fat you have will effect the long term storage of the benzos and the active metabolites. If you decide to start working up a good sweat, and losing weight, you are potentially opening the flood gates as the stored benzos and metabolites (along with any barbituates you may have stored i.e. fioricet, fiorinal, and some other sources of barbs that are synergistic with benzos, even when dumping as stored metabolites i.e. those tension headache pills and the ham eaten a year ago , can overload your systems ability to metabolize before you stop breathing in your sleep or in a bad Asthma attack. Benzo's are tricky because your limbic system will not build up a tolerance the way your cognition does. You are always chasing the high, relief, the dragon and you will never catch it. Best of luck, be carefull and get to a detox center (not drug counselor or even inpatient psych ward). You need to come down and be monitored while you do. Then and only then ,can you go for help in another bottle or in a group. Doc Scotty (Psychopharmacognosist)  

JonWhosSmart, Community Member
8/ 1/10 10:22am

You fail to mention that benzos have never killed anyone (via respiratory depression and other similar causes, obviously you can still wreck your car) when not combined with other CNS depressants. Benzos are relatively safe drugs, especially when compared to Barbituates which were anti-anxiety pills before benzos. Those were highly unsafe, even when taken as prescribed and not mixing them.

AMANDA, Community Member
9/ 2/09 4:42pm

hell no are you crazy? 50mg will defenitly kill you! my doctor perscribes me 1 mg 3 times a day. i hope this gets to u in time do not take that much you will die!!

JonWhosSmart, Community Member
8/ 1/10 10:20am

Clearly you're uneducated in psycopharmocology; you can't die from taking benzodiazepines alone. There are no reported cases of death by Xanax other than in polydrug abuse. You would pass out LONG before you could acquire and swallow enough pills to kill you.


You can even mix it with marijuana and it will still never kill you.

Mixing it with alcohol however, that's death.


Note; I'm just a college student who knows a ton about pharms. More than these "doctors" at least.

JonWhosSmart, Community Member
8/ 1/10 10:17am

You SHOULDN'T, but you CAN.


Benzodiazepines alone will never kill you. The lethal dose is so high you would fall unconscious from the effects of the drug long before you die of respiratory depression.


If you took 50mg of Xanax, and then any amount of alcohol, you're probably done. Tolerance has an effect but two substances that affect the GABAa neurotransmitter is very dangerous.


However, if the Xanax is taken (it can even be mixed with other benzos like valium and kpins) without any other substances, you will never die from taking it. Bad things will happen, you might forget a week or two, but you will NOT die, and any "doctor" on here who tells you otherwise needs to go back to medical school. I'm 19 and even I know how to research drugs effectively and not just say "10x the rec. dose will always kill you".



diane4321, Community Member
7/28/11 11:42am

You really have an inflated ego to beat the band. Xanax will never kill you is the stupidest statement I have heard in such a long time. I quarentee a woman about lets say 150lbs. takes 150 mg. of xanax at one time and there is no intervention. Most likely she will not wakeup. And there is plenty of time to take that many without falling asleep. I know of two people that died from just taking 90 1mg. tabs. They go into respitory distress and just stop breathing. I swear I don't know how some people can be so dumb. I have worked for hospice and believe me we know. If there were no chance of dieing from an overdose as you are so stupid to suggest then we would just give as much as the pt. wanted. Never say never. You don't know. Are you omnipedent? You have no idea how many people have died from an overdose of Xanax and taken nothing else.

daemon, Community Member
2/21/11 6:41pm

John is correct, benzodiazepines such as Xanax, when taken ALONE, do not cause death through respiratory depression; when mixed with other medications, the chance of hypoxia and death is very real.


There is no valid reason to take 50mg of alprazolam; you will simply pass out and remain unconscious for multiple days, to say nothing of the anterograde amnesia (you will remember nothing of the time the chemical was present after crossing the BBB).


I myself take 20mg of phenazepam a day, but it is an addiction I have been fighting for over eight years now, one so severe that if I miss a day I will literally have a seizure and die.


I cannot in good faith reccomend a dosage any higher than 4mg.

Shinobi, Community Member
12/25/11 1:22am
Hey I just took 60 1mg tablets of Xanax let ya know what happens if I wake up In the morning lol letts see what happens....,. Reply
DeeS1031, Community Member
7/13/13 3:56pm
Whyy in the world would u take that many besides to kill yourself... :( Reply
TheGame, Community Member
11/26/13 8:16am

You should only take the dosage your doctor has prescribed you. If the dosage prescribed by your doctor is not helping your symptoms, then talk with your doctor to determine if a higher dosage is needed before exceeding your doctor's recommended dosage. 50mg of Xanax is quite a lot. I take 1mg 3 times a day, but only if needed.

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By chris, Community Member— Last Modified: 08/14/14, First Published: 09/14/08