That is not a prominently advertised side effect of the drug. I assume that your doctor noted the sudden spike in cholesterol (or is it coincidental that you simply had a cholesterol profile done at this time and could the spike have been occuring over a period of time) and I assume he knows you started this drug - what did he say? If your emotional state is more balanced thanks to the Lexapro - have you suddenly developed a significant appetite and could that be responsible for the spike?? Are you on any other medications that could be causing this spike?? I would discuss the issue with my doctor