dewalt - As a general rule always discuss matters of concern with your physician. The effects of discontinuing treatment are influenced by the dose taken and the length of time you have been on it, among other factors. Research data suggests that in 2% or more of the patients studied, abrupt discontinuation of treatment resulted in symptoms like dizziness; nausea; headache; paresthesia; vomiting; irritability; and nightmare. Although it seems unlikely that missing only one dose would cause problems, it is not impossible. Again, speak to your physician in order to be sure that there is nothing to worry about.   Rick Wirtz   Rick Wirtz is a Psychologist, not a psychiatrist or medical doctor. Although the majority of Psychologists are not authorized to prescribe medications or give you specific advice about them, they typically have experience working with patients who take a variety of medications. The response above is not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only and primarily to aid you in having an informed discussion with your own physician