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Hi Stacey,   Show the specific sinus medication you want to take to your Pharmacist and ask him/her if it's o.k. to take. The following are known to have interactions with Cymbalta, but this is not meant to be an all-inclusive list: fluvoxamine sibutramine thioridazine tryptophan  .....these four were listed as "very serious" and potentially "fatal"     The information also states to talk to your doctor or pharmacist before taking any high blood pressure medication, and aspirin or ibuprofen or any herbal or over the counter medications.   Regards, Dr. Jennifer Fee www.drjenniferfee.com www.thestressmasters.com     *Dr. Fee is a Psychologist and does not prescribe medication. The comments in this post are not meant to diagnose or treat any mental/medical disorder. They are merely to give you more information so that you can have an informed conversation with your physician.