• J.T. Aylsworth J.T. Aylsworth
    March 05, 2009
    Suggested replacement for Serzone
    J.T. Aylsworth J.T. Aylsworth
    March 05, 2009

    I took Serzone for approximately 3 years with very positive results. When Serzone was removed from the market I was prescribed Lexapro, then Citalopram, then Buspirone with Alprazolam as needed. None of these had the benefits of Serzone. Is there a suggested equivalent to Serzone?



  • Eileen Bailey
    Health Guide
    March 06, 2009
    Eileen Bailey
    Health Guide
    March 06, 2009



    Thank you for your question and welcome to AnxietyConnection.com.


    I am not a medical professional and would not be able to recommend medication for you.


    There are many different medications available for depression/anxiety on the market today. Since people react to medications differently, finding the right medication and the right dosage is often a matter of trial and error. Unfortunately, it sounds as if you have been trying unsuccessfully to find a medication (that doesn't cause liver damage) that will work for you.


    Hopefully, you will be able to continue to work with your doctor to find the right medication.


    For more information on the medications available


    Anxiety/Depression Medications


    I am sorry I could not have been of more help




  • GeoSeattle July 01, 2011
    July 01, 2011

    I take the generic form of serzone, Nefazadone. It works extremely well for me, just as serzone did. But, I did not know Serzone was taken off the market... Why?

    • italiangm
      July 05, 2011
      July 05, 2011

      Serzone (nefazodone) caused life-threatening liver problems in a small percentage of people taking it. 


      Depending on the country/region, the range of actions taken on serzone/nefazodone has been:


      -- to institute prescribing limitations

      -- to voluntary market withdrawal by the pharma co

      -- a government ban


      I was on it myself for over a year around 2000. Didn't do much for my panic disorder symptoms but turned me into a vegetable between 200mg and 400mg.


      Got really nauseous xmas 2000. Couldn't keep anything down so stopped taking it. Learned about the FDA's warning about a year later.  Don't know if my nausea was due to serzone, but subsequent liver enzyme tests during my annual physicals showed no damage. :)


      The closest med to nefazodone is trazodone but it puts most people to sleep.

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