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Thursday, March 05, 2009 J.T. Aylsworth, Community Member, asks

Q: Suggested replacement for Serzone

I took Serzone for approximately 3 years with very positive results. When Serzone was removed from the market I was prescribed Lexapro, then Citalopram, then Buspirone with Alprazolam as needed. None of these had the benefits of Serzone. Is there a suggested equivalent to Serzone?

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Answers (2)
Eileen Bailey, Health Guide
3/ 6/09 12:05pm



Thank you for your question and welcome to


I am not a medical professional and would not be able to recommend medication for you.


There are many different medications available for depression/anxiety on the market today. Since people react to medications differently, finding the right medication and the right dosage is often a matter of trial and error. Unfortunately, it sounds as if you have been trying unsuccessfully to find a medication (that doesn't cause liver damage) that will work for you.


Hopefully, you will be able to continue to work with your doctor to find the right medication.


For more information on the medications available


Anxiety/Depression Medications


I am sorry I could not have been of more help



GeoSeattle, Community Member
7/ 1/11 2:28am

I take the generic form of serzone, Nefazadone. It works extremely well for me, just as serzone did. But, I did not know Serzone was taken off the market... Why?

italiangm, Community Member
7/ 4/11 8:19pm

Serzone (nefazodone) caused life-threatening liver problems in a small percentage of people taking it. 


Depending on the country/region, the range of actions taken on serzone/nefazodone has been:


-- to institute prescribing limitations

-- to voluntary market withdrawal by the pharma co

-- a government ban


I was on it myself for over a year around 2000. Didn't do much for my panic disorder symptoms but turned me into a vegetable between 200mg and 400mg.


Got really nauseous xmas 2000. Couldn't keep anything down so stopped taking it. Learned about the FDA's warning about a year later.  Don't know if my nausea was due to serzone, but subsequent liver enzyme tests during my annual physicals showed no damage. :)


The closest med to nefazodone is trazodone but it puts most people to sleep.

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By J.T. Aylsworth, Community Member— Last Modified: 01/02/13, First Published: 03/05/09