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Tuesday, October 18, 2011 lburgess, Community Member, asks

Q: How Long Does It Take Zoloft To Work For Anxiety?

I'm taking Zoloft and just want to know how long it takes for it to be fully in my system. Thanks!

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Answers (2)
Eileen Bailey, Health Guide
10/18/11 9:18pm

Thank you for your questions and welcome to


I am not a medical professional and would not be able to give you medical advice.


I did find the following information on National Alliance for Mental Illness (NAMI):

"Disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks and can be an important early signal that the medication is working. Other symptoms such as depressed mood or lack of interest in activities may take 4-6 weeks before improvement is evident.

Like other medications used for anxiety disorders (e.g. PTSD, OCD) sertraline may take several weeks before it is fully effective. It is important to give the medication sufficient time before judging whether or not it will work for a given person."


I hope this helps.



Merely Me, Health Guide
10/20/11 7:27pm

Hi there


As Eileen has mentioned, it can take as long as 4-6 weeks or longer for this medication to reach its full therapeutic potential.  That time period of waiting can seem like forever when you are suffering from anxiety.


Just wanted to add that on our depression site we have a Member Medication Review about Zoloft where our members describe how they fared on this medication.


Please let us know how this medication works out for you.

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By lburgess, Community Member— Last Modified: 08/15/14, First Published: 10/18/11