As of this writing, three medications have been approved by the FDA for the treatment of fibromyalgia: Lyrica (pregabalin), Cymbalta (duloxetine) and Savella (milnacipran). Since all three are relatively new drugs, information on how well they work and their side effects is still being gathered. Because every patient's symptoms and body chemistry are different, it is often a matter of trial and error to find the best medication for a particular patient with a particular illness. However, a recent German study , which was the first to compare the pros and cons of the three drugs head-to-head, may help doctors choose which medication has the best chance of success for any given patient. Study Design The study authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health, and Industry through May 2009 for randomized controlled trials. They found 17...
Generic name: Duloxetine
Cymbalta is an antidepressant medication. It has been approved for use in treating symptoms of depression and generalized anxiety disorder (GAD). It is also used to treat fibromyalgia and diabetic neuropathy. Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Serotonin is a neurotransmitter in the brain and depression has been linked to the inability to create enough serotonin. Norepinephrine is another neurotransmitter linked to depression. Cymbalta targets both serotonin and norepinephrine, unlike SSRIs, which only target serotonin. Both of these neurotransmitters can impact mood. The medication works to block the neurotransmitters from reentering the nerves, allowing more of the neurotransmitters to remain active.
Clinical trials have shown Cymbalta to improve mood, increase appetite and allow for better sleep. It can also increase energy and decrease nervousness.
Generally, this medication is started...
You've probably seen the television commercials or magazine ads for Cymbalta, and you might be wondering what makes it different from other antidepressants. Since I know that the writing in the medication insert is dense enough to make your eyes cross and your head nod, I've distilled some of the basic information about it here.
Cymbalta (duloxetine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) prescribed for the treatment of depression, anxiety, stress urinary incontinence, nerve pain and fibromyalgia. Other antidepressants in the SNRI family that you may have heard of are Effexor and Serzone. SNRIs act on two neurotransmitters in the brain, namely serotonin and norepinephrine, to prevent their reabsorption after they act on receptors.
As with several other SNRIs, Cymbalta's most common side effects are nausea, dry mouth, drowsiness, headache, changes in appetite, vivid dreams, dizziness and sexual side effects. This is ...
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