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I stopped my Effexor 2 weeks ago because my insurance company said they would no longer cover this drug unless you meet the guidlines, which they said I did not. My doctor has been on vacation so I can do nothing, I have went off my medication many times over the years because I didnt want to take medication. I have learned the hard way I have to have it to function and not be agressive towards others and yell and scream at everyone. I do the same thing your wife is doing and I'm not at that point just yet I guess because I also take Cymbalta, but I was informed I dont meet the guide lines for this drug too, so when I'm out I dont know what will happen, but I know it wont be pretty. I am so tired of the insurance company telling us who we can see and who is not in "our" network and how many days they will pay for our patients to be in the hospital, and now if you meet the guidelines for a medication. That should be up to the doctor. Sorry for going off the track, but yes I know what your wife is going through and I'm so sorry, she needs to take her meds. And I hope everthing works out. I'll keep you all in my prayers!!