I am not a physician this is the informatio I came up with

Pharmacokinetic At  man, the oral amounts are well absorbed. The plasmatic concentrations are proportional to the amounts: for posologies between 0,5 and 3 Mg, the concentrations of point vary between 8 and 37 ng/mL. The half-life d' average elimination of  alprazolam is  approximately 11 hours in the adults in health. After amounts multiple, managed 3 times per day, balance dynamic is reached in 7 days or less.  urine is the principal way d' excretion of the product and its metabolites. alprazolam is degraded mainly by oxidation, involving the formation of the primary metabolites:  alpha-hydroxy-alprazolam and a derivative benzophenonic. The metabolite alpha-hydroxy is then transformed into déméthylalprazolam. The metabolites alpha-hydroxy and déméthylalprazolam are active, and their half-life seems similar to that of the product, but they do not find qu' in small quantities in plasma. Table 1 summarizes some of the pharmacokinetic parameters observed on adults and elderly in good health (70 years Middle Age, variable between 62 and 78), like on subjects suffering obesity or  hepatic or renal insufficiency. The clearance decreased and the half-lives increased at all the populations of special patients, with exception of the patients on hemodialysis. The plasmatic concentration of point was reached more tardily among patients suffering  hepatic insufficiency and those under DPCA (dialysis péritonéale continues ambulatory). Cimétidine: The cimétidine blocked the clearance of  significantly; alprazolam and prolonged its half-life. One administrated with volunteers in good health a single amount of 1 Mg  alprazolam with and without cimétidine (300 Mg) every 6 hours. The cimétidine significantly reduced the total metabolic clearance (1,05 against 1,66 mL/min/kg) and prolonged the half-life significantly; elimination (16,6 hours against 12,4 hours).  repeated administration of the 2 drugs produced similar results. Oral contraceptives:  was studied; effect of the oral contraceptives on pharmacokinetic the  a single amount of 1 Mg alprazolam among women in good health. The clearance of  alprazolam was weaker among women taking of the oral contraceptives (0,95 mL/min/kg) that in the reference group (1,21 mL/min/kg) and its half-life was prolonged (12,4 hours against 9,6 hours). Anticoagulants: Three amounts of 0,5 Mg alprazolam per day, during 14 days,  do not have affected the time of prothrombine nor the plasmatic warfarin concentrations at male volunteers having received sodic warfarin by oral way.