Hi Mary,   While I am not a doctor and can not give you advice about medications, I can point you to some information that might help you ask all the right questions when you talk to your doctor.   Buspar (buspirone) is a medication for anxiety (anxiolytic) that works by affecting certain natural substances in the brain (neurotransmitters). You can read about Buspar here and about drugs that are generally used to treat anxiety here in the drugs database. There is a warning against taking this medication with any narcotic pain relievers which I believe might include the Percocet.  You can read about the interactions here.   I know how it is when you feel over medicated and feel like the medicines you are taking are not working properly. The best thing to do is discuss this with your doctor with a list of everything you take and armed with the possibility that there might be a drug interaction going on here.   Remember, your doctor has prescribed you a medication that has some side effects associated with it, but the benefit was deemed to be more important than the side effects. So have a talk with your doctor and see what he/she says. It never hurts to get a second opinion either.    There are also other members who have similar experiences as you, with other medications. Donnalyn is a member here who has had a similar issue with klonopin. I hope something here helps.   Take care and stay in touch!   Vicki M