I just started taking the generic effexor, not xr, and I am seeing a big difference. I am back to the way I was before I started taking anti depressants. I cry over ever little little. However, it is helping me with my appetite. Before, on effexor xr, I could eat and eat and eat. Now, I have very little appetite. I am not sure which road to chose because I sure did gain about 20 pounds on it.