29 years since my first DSM diagnosis and after the first decade or so the 'usual' ADs are more toxic than a treatment. I have been hospitalized twice for Serotonin Syndrome, one time put me in a mild-moderate coma for almost three days.  SSRI's/SNRI's/tricyclics and others have opposite, negative effects on my anxiety--mostly by exascerbating them. I am on multiple medical record that I cannot take adergenic-affecting medications. i am now only limited to a solely BZD regimen. I have and still continur to practove exerces such as TM, visualization, graded exposurre, CBT, interpersonal therapies, etc. with limited success. Other co-morbitities and other diagnoses have been investigated, only to be dismissed. I have been on almost every AD including mnay combinations, some with BZD's other times with none. Three decacades with no signficant mprovements have me more than frustrated. The condition continues to be a severe detriment in many aspects of my life.