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Hi Carrie: All the antidepressants carry with them the potential of weight gain. If you look at Wellbutrin, for instance, you will see weight changes are likely, and it is also true in Lexapro.  Abilfy is a very different class of drug than Lexapro and you can read about its side effects here. You should consult with your physician about the best medication combination for you and the one with the lowest risk of weight gain, if that is your primary concern. If you want to learn more about depression, check out the website My Depression Connection. Remember, all medications carry side effects and you should learn what you can, and ask your physician about the risks involved.   I hope this helps, Dr. Diana Walcutt The Stress Masters   *Dr. Walcutt is a Psychologist, not a Psychiatrist. Psychiatrists prescribe medications. Psychologists study them, but the majority of Psychologists are not authorized to prescribe meds or give you specific advice about them. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.