Michael - Seroquel can be helpful to quiet agitation, severe anxiety, and improve sleep. It can also be very sedating and decrease motivation. Hopefully the doctor prescribing the medications is an expert in treating individuals with head trauma and has taken this into account in the dosing of the medications. If she is very unmotivated a decrease in the dose of Seroquel may be necessary. Ritalin can also have a detrimental effect on sleep so the dose and the timing of the dose is important. Intake of caffeine and nicotine should also be taken into consideration.   Rick Wirtz   Rick Wirtz is a Psychologist, not a Psychiatrist. Although the majority of Psychologists are not authorized to prescribe medications or give you specific advice about them, they typically have experience working with patients who take a variety of medications. The response above is not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only and primarily to aid you in having an informed discussion with your own physician.