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Hi Phyllis: I hear this problem from patients frequently -- both men and women complain of decreased libido with medications. While I'm not a physician, I have asked two friends who are psychiatrists which antidepressants have the best side effect profile and have been told that Wellbutrin would be the most widely prescribed medication for depression had it appeared on the market before Prozac. They maintain that sexual side effects are fewer with this medication. When you read the side effect profile on any of the antidepressants, you are likely to find decreased libido as a side effect, with the possible exception of Wellbutrin.  For instance, when you look at Effexor, you will find essentially the same warnings, including sexual side effects, as you will under Prozac.      Unfortunately, you are on a number of medications and it's possible that one medication alone may not be the problem. You should consult with your physician about the mixture and determine what combination is best.   However, remember, all medications carry side effects and you should learn what you can, and ask your physician about the risks involved.   I hope this helps, Dr. Diana Walcutt The Stress Masters   *Dr. Walcutt is a Psychologist, not a Psychiatrist. Psychiatrists prescribe medications. Psychologists study them, but the majority of Psychologists are not authorized to prescribe meds or give you specific advice about them. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.