Desyrel Oral

Desyrel Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

• sibutramine
• triazolam

If you are currently using any of the medications listed above, tell your doctor or pharmacist before starting trazodone.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• other antidepressants (e.g., amitriptyline, bupropion, fluoxetine, nefazodone, venlafaxine)
• digoxin
• drugs affecting liver enzymes that remove trazodone from your body (such as azole antifungals including ketoconazole/itraconazole, HIV protease inhibitor drugs including atazanavir/indinavir/ritonavir, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifampin, St. John's wort, certain anti-seizure medications including carbamazepine)
• other drugs that can cause bleeding/bruising (e.g., anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen)
• drugs for high blood pressure
• ginkgo
• MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that may cause drowsiness. Ask your pharmacist about using those products safely.