Cymbalta Oral

Cymbalta Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Certain medications taken with this product could result in serious (rarely fatal) drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) with duloxetine for 2 weeks before treatment, during treatment, and at least 5 days after your last dose of duloxetine. Consult your doctor or pharmacist for more information.

This drug should also not be used with the following medications because very serious (possibly fatal) interactions may occur:

• fluvoxamine
• sibutramine
• thioridazine
• tryptophan

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting duloxetine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• drugs removed from your body by certain liver enzymes (e.g., cimetidine, antipsychotics such as perphenazine, antiarrhythmics such as propafenone/flecainide/quinidine, certain quinolone antibiotics such as ciprofloxacin, antidepressants such as desipramine/fluoxetine/imipramine/paroxetine)
• drugs to treat high blood pressure (e.g., clonidine, guanethidine)
• "water pills" (diuretics such as furosemide)
• drugs that can cause bleeding/bruising (e.g., aspirin, antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as heparin/warfarin)

Aspirin can increase the risk of bleeding when used with this medication (see above). If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Discuss the risks and benefits with your doctor.