Don't be Afraid of Using Advair and Symbicort

By Rick Frea, Health Pro Monday, March 29, 2010
So what's the deal with Advair and Symbicort?  These meds have helped so many asthmatics finally gain control of their asthma, yet, with all the recent warnings,  the FDA seems to be wary of these meds, and this is scaring people.   Should we be wary and quit taking them?&n...
Seven Best Exercises for Asthmatics
4/ 1/10 4:08pm

I was given serevent early in 1998 when I was first diagnosed with asthma.  I almost became a statistic.  I experienced heart problems which completely exhausted me.  I suspected the serevent because it was the only new thing in my medical arsenal.  One night I took the first puff on the serevent inhaler and passed out.  When I woke up, I decided not to take the 2nd puff.  My doctor assured me that the serevent could not be responsible. I missed a week of work and was diagnosed with a heart irregularity.  About a year later, I read articles of asthmatics found dead clutching there Serevent inhaler. I think the 2nd puff would have done it.  Serevent is the LABA in Advair.    Haven't been near it since.  I have my asthma under control with Flovent. 

4/ 1/10 6:33pm

I took Advair for 3 or 4 days and then saw my doctor for a swollen face and lips on one side.  Looked like I had a stroke or Bells Palsy.  It starting going away

the next day.  It may be wonderful for some, but not for all.

 

4/ 3/10 8:07pm

http://saltchalet.blogspot.com/ I know I just posted a comment but I thought you'd might be intrested in these natural treatments.

4/ 1/10 8:17pm

I don't understand. I thought that asthma was reversible, and COPD wasn't.  So how can Advair improve lung function if you have COPD?

4/13/10 5:02pm

asthma is NOT reversible it is a lung dsease. you can strengthen up your lungs and you can improve symptoms of it like if allergies,exercise,extreme cold/heat cause flare ups then you can control those to lessen the severity of asthma but asthma is something that is not reversible you can go years without symptoms and then one day have a full blown asthma attack.there is No such thing as outgrowing asthma as recent studies show.as for COPD it can be mistaken for asthma or vice versa COPD is a breathing/lung problem like asthma

Anonymous
Becca
3/31/12 10:06pm

 asthma is not reversible. I have food and seasonal allergies.

I have been using symbicort which is helping. Everything has pros and cons.

This is a maintenance inhaler to help get better control of the asthma. 

I don't read the side effects of any meds until I notice some negative reaction. I have my family read them and help me watch for anything abnormal.

James Thompson, MD, Health Pro
4/ 2/10 8:40pm

Hi Rick,

 

I had planned on posting an article about Advair, Symbicort and the new FDA bulletin / and old Black Box Warnings. But you beat me to it. I must say you did a fine job! I agree with your commentary and assessment.

 

As noted in some of the above comments, some individuals have had some severe side effects from palpitations and more rarely, allergic type reactions. But I have had tens of hundreds of children and adults on Advair (and Symbicort). My patients have remarkably done well in tolerating and benefiting from these combination inhalers. You are right, in Europe and Canada, there is not nearly the expressed concern among policy makers, about side effects, that we see in America (by the FDA).

 

Although combination inhalers are not a cure-all, asthma has become easier to treat for many specialists that manage asthma patients. We have seen asthma death rates go down over the last 10 years since new medications and guidelines have been available. We can't say this is directly a result of Advair or Symbicort, but I think they have played a part in it.

 

Again, excellent article! People should not be afraid of these inhalants that have helped the majority of asthma patients who use them. If they are in the small minority of people that are intolerant of them, there are of course other alternatives.

 

J. Thompson, Allergy and Asthma Specialist

4/ 3/10 6:51pm

Dear experts have any of you heard or tried Halotherapy? (also known as salt rooms). I'm asking this because I've been suffering from COPD for some time now and got exusted with all the midecations(!) when one fails to help you, just pop another one... Not anymore. These treatments have been helping me a lot and have made a big diffrence in my condition and have no use for those drugs anymore.   http://saltchalet.blogspot.com/

4/15/10 4:47pm

I'm also an RRT and patient educator therapist in Wyoming and we just heard from Dr Hedgwood who is head of the pulmonary testing and research lab at the University Medical Center in Utah.  He also agreed with Dr. Minz on the LABA and the use of Advair & Symbicort as long as patients posses a FABA inhaler. Rick in WY.

2/26/11 4:45pm

I would be interested if the writer is paid by GSK or an employee.  "Any" drug associated with or suspicous of causing sudden death should not be put on the market whether it be a "miracle" drug or not.  90% of the users of Advair are first-time users of the drug.  Nobody has studied the effects of Advair or Serevents effects on long-term asthmatics.  To say the "death of a few outway the health of many" is not only an ignorant statement, but has now become a business "catch-phrase" to play on the physic of the asthmatic.  The popularity of Advair is not attributed to it's benefits, but to the ability of GSK's sales force to push the drug and any drug down the throats of doctors.  We speak of the "black box warning".   First, the "death" warning is not on the disk or the box.  The "death" warning is buried in the enclosed drug information sheet that is folded extremely tight, taped and once you fold it out you need increased focal help to read it.  I would be more impressed with GSK if the warning is on the disk.  Do you think that will happen?  Should it happen?  What does it matter you might ask.  I can tell you.  It will cut into GSK's sales or let's just say "money".  There are many medical professionals that have suggested this drug be removed from the market.  If you take the time to research any of this you'll find those that are opposed to Advair are objective with nothing to gain.  However, if you research and find many many medical professionals and research that support Advair you'll discover they either work for, paid by or have some affiliation with GlaxoSmithKline.  There are many other asthma drugs available.  Don't go to your primary care physician, there idiots and quite lazy about asthma.  The only thing doctors know about asthma and Advair is what the GlaxoSmithKline salesmen tell them.  How many doctors do you know have the time to read about all the drugs on the market.  They don't have enough time to treat us for a splinter.  Don't be duped by those who think they know.  Do the research (hard work) and find out for yourself. 

Rick Frea, Health Pro
3/ 1/11 4:18pm

Jerry:  I just thought you'd like to know I am in no way associated with GSK.  I am one of many asthmatics who have benefited from Advair, and have been taking it for many years.  Before Advair my asthma was uncontrolled, and with Advair my asthma is controlled.  I know many asthmatics who take the same medicine.  To take a medicine like Advair off the market based on a black box warning would be to doom a nice asthmatic like myself (and my asthmatic friends and patients) to a world of hardluck asthma.  I've been there and don't want to go back.  The decision to weigh the risks and benefits of a medicine like Advair should be up to the individual asthmatic and asthma doctor. 

3/ 1/11 10:08pm

Once again, as many do, the big picture is avoided.  I don't blame you for standing up for what you "believe" is right.  God bless you for that.  But does it make it right?  Many leading doctors have spoken out about Advair.  Why??? I thought it was because they were part of a lawsuit or benefited in some way.  I couldn't find that relationship anywhere.  However, I can't believe it's your only recourse.  There are many alternatives and new ones coming.  Even GSK is releasing Relovair in 2013 or 2014.  I'm assuming they've had enough with Serevent and Advair.  But !! We'll find out how good Relovair is.  Hopefully it's not delivered by powder.  Wait.... did I just say powder.  By everything that's logicaly and reasonable, why would anyone inhale powder particles into their lungs?  One last thing.  Drugs work differently with each of us.  That's why there are so many side effects listed.  Advair may work for you, but is it ethical that it should remain on the market when even one person dies after using it?  If you're on the "band wagon" of the few outweigh the many, then you and your friends have no concept of the love of humanity and your fellow man.  When my daughter (asthmatic for 22 years) died this past month after starting Advair and wasn't able to make it to the emergency room that's when I began researching Advair.  I was only researching why my daughter died so quickly.  She trusted her doctor.  She went into distress within minutes.  Do you think that bends my objectivity?  No!  I spent hours, days and weeks looking into why she died so quickly.  My research reveals that Serevent and Advair should never have been allowed into the market, especially the US market.  Deaths haven't dropped.  Asthma prevalence is growing into the millions.  Doctors don't care.  They're just ignorant pawns of the drug company salesmen and saleswomen.  Do asthmatics and yourself a favor, stop inhaling powder and look for something else.  Who knows, you may just be a ticking time bomb for lung collapse.

3/ 4/11 12:55pm

Jerry,

I'm so sorry to hear about your daughter.  This is truly tragic, since the dangers of Advair have been known for a number of years now, as you probably have discovered.   

I took Advair for a couple of weeks (free sample), a few years ago, and thought my lungs felt "twitchy," as if I were always on the verge of having an asthma attack -- so I stopped it.  It was only later (2004) that I found out about the dangers of Advair -- really, Serevent, the LABA (long-acting beta agonist) component of Advair -- via the testimony of Dr. David Graham of the FDA (one who believes LABAs should be taken off the market), before a Senate committee, which I viewed on C-SPAN (http://www.cbsnews.com/stories/2004/12/07/health/main659529.shtml). 

Indeed, more recently (2010), the FDA has questioned whether clinical trials should be performed to determine whether there is a safety risk with Advair and similar combination drugs containing a LABA.  Dr. Graham and another colleague have shown that there already is enough evidence to conclude that Advair and similar drugs pose a safety risk, including death.  I wrote about this in these posts: 

http://www.healthcentral.com/asthma/c/962/113137/comments?desc=asthma-effectiveness#c246153


http://www.healthcentral.com/asthma/c/962/113137/comments?desc=asthma-effectiveness#c246416

Also, from http://www.naturalnews.com/020107.html

Adding an anti-inflammatory drug to a long-acting beta-agonist adds little benefit, report the Salpeters [two of the authors of a meta analysis (statistical analysis of a number of clinical trials)] . Advair [my emphasis], for example, (the fourth bestselling drug in the world with $5.6 billion in annual sales [in 2005]), combines salmeterol with an anti-inflammatory drug to provide some protection against bronchial inflammation associated with beta-agonists. But hospitalizations still doubled for patients inhaling a long-acting beta-agonist combined with an anti-inflammatory drug compared with asthma patients taking a placebo and an anti-inflammatory drug by itself.

[I should add that deaths were reported with the use of Advair, as well.]

As to your claim, Jerry, that powder is to blame for the dangers of Advair, I should point out that Advair is also available in a "traditional" medicated-dose inhaler (MDI) (http://www.advair.com/asthma/if-you-are-taking-advair/using-the-advair-hfa-inhaler.html), so I don't believe the powder is to blame, but rather the LABA component of Advair.  I'm sure this is cold comfort to you, however.  Relovair, in fact, scares me even more (my opinion only), since it is designed to be used once a day, not twice a day, like Advair, and thus, the drugs (most alarmingly, the LABA component) should stay in your system longer.


 


3/ 4/11 10:19pm

Tanfan... thank you for the information.  I'm not quite sure "I was blaming the powder" delivery via the Advair Diskus.  I was attempting to point out, does it seem logical to inhale powder?  I don't know of any studies that have been able to look inside the lungs to view what could be happening to those patients that use the powder form.  I've had a chance to talk to Dr. Salpeter.  Unfortunately her father has passed: truly a genious.  What hurts the most is that I didn't know about the studies or the "hidden" black box warning until after her death. Thanks again for the info.

3/ 5/11 3:24am

Jerry,

Thank you for your kind words.  I only wish (of course) there were some way to bring your daughter back.  Your account truly shook me, as I figured it could have been me.  While I can sympathize with those like Rick, who apparently have been helped immensely by Advair and similar combination drugs, I feel the drug companies have done everything in their power to suppress the "bad news" about these drugs -- even fighting tooth and nail to keep the "black box" warnings from being issued -- just to protect their profits, of course. 

I can only thank those like the Salpeters, and Dr. Graham, who have helped illuminate the dangers posed by Advair and similar drugs (I would thank them in person, if I could -- and thank you for telling me of Dr. Edwin Salpeter's passing; he truly performed a service to humanity) -- because while statistically, the risk posed by these drugs may be small, they are real -- and no one should take these drugs even once, without knowing the risk they are taking.  I, myself, took -- and my doctor prescribed -- Advair, without knowing these risks, since they hadn't been brought to the attention, yet, of the general public, since at that time, Advair didn't have its "black box" warning.

Even now with the black box warnings, it is evident right here on these boards, how willing people are to "sweep under rug" any dangers posed by Advair and similar drugs, given how many people have taken them, apparently with great success.  If you just happen to be one of the "unlucky" ones, though, too bad -- as any risks are clearly downplayed, and almost pooh-poohed -- induced by the groupthink, I believe -- promulgated by the drug companies determined to protect their profits. 

As an aside, it appears that clicking on the links I have provided in my post above doesn't work; copying and pasting them to your browser, though, should work, as they are not (as of this writing) dead links.

4/ 1/11 10:31pm

I am wondering if anyone knows of any studies relating to the increased risk of  instances of Leukemias, such  AML or its subsets, in users of Advair and Symbicort.

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By Rick Frea, Health Pro— Last Modified: 03/31/12, First Published: 03/29/10