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Thursday, November, 12, 2009
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Asthma Risk and Acetaminophen: Mounting Evidence

James Thompson, MD
James Thompson, MD
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James Thompson, MD is How are you doing?
Board Certified Allergist and Internist

I spend most of my time treating patients with asthma and allergic...

James Thompson, MD

Monday, September 29, 2008
View All of James Thompson, MD's Posts
It is disturbing that as we enter peak cough, cold and flu season, we are faced with the dilemma that acetaminophen (sold under the brand name Tylenol) may increase the risk of developing asthma.   The last major Tylenol scare occurred in the 80s when a few pill bottles were tainted with cyani...
  1. motrin
    Anonymous
    Sunday, October 05, 2008 at 11:54 AM

    Dr. Thompson,   Is it okay to give my child motrin if she has a fever? Should I avoid tylenol because of her risk of getting asthma? Will she get the reye syndrome if she gets motrin or ibuprofen? What am i suppose to do?

    Reply
    re: motrin
    James Thompson, MD
    Monday, October 06, 2008 at 10:28 AM

    Hi,

     

    Thank you for your questions. I suspect a few other readers of this posting share your concerns. I cannot advise particular medications for you to give your child through this medium. My posting should not, at this point lead to any major change in the approach to managing fever in children or adults. There is not enough information supporting the acetaminophen (Tylenol) connection with asthma to advise avoidance at this point.

     

    That said, health experts recommend not giving aspirin to children (those under age 18) for treatment of fever, viral syndromes and upper respiratory tract infections because of the risk of Reye's syndrome. Here is a link to a very good review on Reye's syndrome.

     

    Furthermore, a small percentage of children and adults with asthma may have severe wheezing and shortness of breath (asthma attack) after being given ibuprofen (Motrin, Advil and many other brands) other related pain killers or aspirin. About 6-8% of asthma patients have this hypersensitivity.

     

    Most reports have not associated ibuprofen and related drugs with Reye's syndrome. A few reports warn that the risk of this serious disease may be increased by ibuprofen because of its similarity to aspirin (similar mechanism of action). Again, this is why Tylenol became so popular over the last three decades.

     

    So, what do you do?

     

    Avoid giving your child aspirin unless advised by your doctor. Ask your family doctor or pediatrician whether acetaminophen or a brand of ibuprofen is preferred for treating fever or mild pain relief.

     

    Best of Luck!

     

    J. Thompson, MD

     

     

    Reply
  2. Untitled Comment
    Anonymous
    Thursday, November 05, 2009 at 11:43 PM

    Two things that don’t make sense to me:

     

    First: Aren’t babies and kids who have asthma more prone to severe illness that requires parents and doctors to treat with Tylenol and other drugs? So isn’t it possible that Tylenol use just occurs more frequently with kids who have asthma, and it did not, in fact, cause their asthma?

     

    Second: The most strong risk factor for asthma, statistically, is genetics, followed by never having received breastmilk.
    Those seem like more obvious culprits.

    Reply
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