Affecting an estimated 4 1/2 million people in the United States, Alzheimer's disease (AD) is expected to become a growing medical, social, and economic concern as our elderly population expands. It is expected that AD will exert an increasing burden on all aspects of society as the number of patients affected by AD will only continue to increase. The most common cause of dementia, an effective cure for AD remains elusive. Current treatments are limited to improving symptoms, yet lack the ability to stop disease progression. Several cholinesterase inhibitors are available, which improve cognitive function by improving communication between surviving brain cells. These include Aricept (donepezil), Exelon (rivastigmine) and Reminyl (galantamine). Another medication, memantine, also improves cognitive function and may also have some protective effect. Nonetheless, patients treated with any of these medications eventually exhibit relentless decline in function. Developme...
In a recent story that I wrote for this blog, Rat research and media hype, I pointed out that rat research can be overtaken by media hype. It now appears that mouse research also is capable of being blown out of proportion. First some background: there’s a type of diabetes in mice that’s called NOD diabetes. It’s used as an experimental model to test ideas about treatment and prevention of diabetes. So, anyway, there’s a flurry of recent news items about Canadian research that according to one story, Scientists Cure Diabetes In Mice “amazingly diabetic mice tested healthy virtually overnight.” The actual article, from the journal Cell has an appropriately jargony title: “TRPV1+ Sensory Neurons Control ? Cell Stress and Islet Inflammation in Autoimmune Diabetes”, and again the media is overreacting to some very preliminary (although important) work. As a more cautious reporter adds: “The Canadian researchers caution that any actual treatment for humans is years away, but say it's st...
Mouth ulcers are sores or open lesions in the mouth.
See also: Canker sores
Oral ulcer; Stomatitis - ulcerative; Ulcer - mouth
Causes, incidence, and risk factors
Mouth ulcers are caused by many disorders. These include:
Herpes simplex ( fever blister )
Oral lichen planus
The skin lesion of histoplasmosis may also appear as a mouth ulcer.
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