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Sunday, June 28, 2009 Lavonia, Community Member, asks

Q: Exactly what is the difference between Prednisone, Prednisolone, and Methylprednisolone?

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Answers (1)
ikezic, Community Member
5/12/10 4:39am

Both drugs are corticosteroids with essentially the same effects and side effects.

Methylprednisolone is Medrol. It is available as an oral tablet. Methylprednisolone is also available as a parenteral preparation meaning it can be used intramuscularly or, more commonly intravenously. Prednisone is given orally.


In terms of equivalence, prednisolone 4 mgs= prednisone 5 mgs.

Basically, there are no significant differences in effects and side-effects.

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By Lavonia, Community Member— Last Modified: 12/20/13, First Published: 06/28/09