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Atypical Antipsychotics

By HeyJude Thursday, October 30, 2008

Many of us take the newer (atypical) antipsychotics.  They include abilify, risperdal, zyprexa, seroquel and geodon.  They are all in the same family of drugs, but each is unique and different.

 

The pharmaceutical companies that manufacture these drugs (all of them) currently have various product liability lawsuits against them concerning the atypicals.

 

I've done a bit of research on Abilify - it's a med I put in my body every day and I am concerned about its safety.  Here are my findings:

 

1.  Risk of Diabetes and Hypoglycemia:  Lawers and their clients have lawsuits in various states around the country regarding serious problems people have encountered from taking abilify.

 

NOTE:  My doctor and I have discussed these risks.  He orders tests periodically for diabetes and I am monitored for hypoglycemia.

 

2.  Dementia in Elderly Patients:  Several elderly patients have had complications causing stroke and/or death.  Lawsuits have ensued.

 

3.  Prescribing Abilify to Children:  Doctors have gone off-label and prescribed abilify to children when it was not intended for them.  There are many pending class action lawsuits out there.

 

Based on this info, I will continue to take abilify in spite of the risks.  All meds have side effects.  For two years, I took Zyprexa, which has it's own history of problems.  Because I worried all the time while taking it, my pdoc and I decided to give abilify a try. 

 

If we feel comfortable with the med we are taking, I believe we have better success with it.  I have few concerns now about taking abilify, and certainly no regrets. 

 

There are many alarmists out there and we can get caught up in the frenzy.  It's always good to know the facts before jumping to any unnecessary conclusions.

 

Judy

 

Brain Chemistry - Meds
10/30/08 9:36am

It's nice to hear your sensible approach.  I guess our best bet is just to try them out (unfortunately it IS all trial & error, since we're all different) & see which one works best for us.  At least we find out within days, not 4-6 wks like with the anti-deps.

 

At the same time, it is important to be aware and educated about the side effects & address these with your doctor should they become a concern.  I get upset when I hear of doctors that just gloss over the side effects, even though some can be quite debillitating.  I'm lucky my pdoc has a very good dietician on staff who helped me lose the 30 lbs I immediately gained when I was put on Zyprexa.  The sexual side effects of the SSRI's are my biggest nemisis these days, and I'm so glad that I have lamictal to help me more & more in this department, so I don't have to take such a large dose of my Prozac anymore.  It also helped when I went off the birth ctrl pill, which interferes with lamictal, and can cause depression in itself.  So doing the research is paying off...

 

It's a fine balance of managing the illness & the side effects that can sometimes be as debillitating as the illness.  But again, we are all different, and it's worth exploring which med(s) will work for you in the long run.

 

On an aside, with regards to the atypicals, I read that most of them augment SSRI's (common knowledge, I guess), but apparently Geodon is one that does not do this, which appeals to me because in the past, with other drugs, that would send me too high... so Geodon is the one I will be trying next - and it seems to have the lowest side effect profile, all around.  But I won't hold my breath, because I remember when Wellbutrin was revered to be God's gift to depression & it screwed me up the worst...

 

10/30/08 3:06pm

just a note, the folks iv talked to who have on going suites against the maker of abilify, their complaints where much like mine, non are witch related to what abilify claims for side effects, headaches, diahrea, ears ringing, very low tolerance to many foods, feeling very strange, just feeling like crap all over, very confused. it just screwes up brain chemistry. you should dig deeper. or dont beleive every thing you read, if its not good for childer something terribly is wrong, plus their admiting fault. Many people have become successsful at going after them, your choice.

Their are other pstings on this site of people who couldnt stand how it made them feel either. good luck

10/30/08 5:04pm

Kody...thank you for sharing your opinion.  It's good that we are able to have intelligent discussions regarding the meds that affect all of us in so many different ways.  Good luck with geodon.

10/30/08 5:12pm

Thanks, Sharon...I always read your posts with interest.  Medications can be a difficult and frustrating issue for all of us.  It's also got to be frustrating as well for our pdocs.  Like you said, it's all trial and error until we find the right combo of meds that give us reasonably good health.

Anonymous
Harry Horton
6/30/11 3:09pm

I was prescribed 1/2 milligram daily of risperdal in late une 2001 and I went right into a condition of irreversible hyperglycemia that I have not been able to eradicate for the last ten years. I lost weight, had a blood sugar reading over 700 when it was diagnosed in July 2003. Along with a diabetes condition that diminished during 2004. However the hyperglycemia and underlying metabolic disturbance I still have.

  Recently in 'the/a May 2010 edition of Schizophrenia Bulletin', an article that delneated the metabolic disturbance that underlies a lot of the side effects of atypical antipsychotics, that is, the metabolic syndrome nature of such side effects, that arises from the atypical antipsychotics, was published. Metabolic inflexibility along with fuel consumption distortions were the major subjects of the article. Furthermore the following study from an August 2010 edition of "Endocrinology and Metabolism" related the following study: "Atypical Antipsychotic Drugs perturb AMPK-dependent regulation of hepatic lipid metabolism" THe excerpt: "Taken together, these data suggest that AAPD-stimulated hepatic dysregulation of lipid metabolism could result from the inhibition of AMPK activity, and pharamceutical means to potentiate AMPK activity would contribute to restore hepatic lipid homeostasis during AAPD treatment." End quote.

  THis study can be read along with the Proceedings of the National Academy of Sciences February 2007 edition medical study from Johns Hopkins, Solomon Snyder et al. researcher; who found that AMPK activity was quadrupled with either clozaril or zyprexa and the blockage of the histamine 1 receptor was responsible for this heightened AMPK activity along with the side effect of weight  gain. (2) Richard Fiddian Green rapid response piece from British Medical journal - though could be the journal Chest, can't recall exactly but definitely its one of these two publications- Schizophrenia and adverse effects of its treatments on mitochondrial metabolism. THis article also has relevancy to the above issues.

7/ 1/11 2:15am

Thanks for the good info.  Was it 3 years ago that I shareposted this?  What a surprise to get a response at this late date.  Thanks again.

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By HeyJude— Last Modified: 11/16/11, First Published: 10/30/08