How can I lose weight while taking Seroquel? It works wonderfully for controlling my bipolar, but I have gone from 140 lbs. to 190 lbs. in the past four months. I am 5'5" and am currently taking 500 mg Seroquel and 10 mg Ambien nightly, along with 100 mg Wellbutrin every morning. I have tried exercise but my weight continues to rise, even though my eating habits have mostly remained the same. Is there a medication to counteract the Seroquel weight gain? If not, what can I do to lose all this extra weight and get back to being healthy?