Thursday, May 31, 2012
Introducing Mood 24/7, a new tool that helps you track your mood from day to day using your mobile phone. Try it today!

Sunday, May 17, 2009 Gatsby asks

Q: I have been Dx with Bipolar disorder by numerous psychiatrist over the years.

I have only tried two mood stablilizer meds (Depakote and Topomax) to no avail. I am not a big fan of Lithium and have always declined that particular prescription. I am now 36 and through personal research have begun to understand the benefit of the above "gold standard" medication of the bipolar world. Dr. Kay Redfield Jamison is my hero! Anyone who suffers from this MH Dx should read her book entitled, "An Unquiet Mind". Wow! Now, my problem is since I have resigned to the fact that I do need treatment and medication administration, I am finding it extremely difficult to locate a psychiatrist that does not see a distinction between being a psychotherapist and psychpharmocologist! Meaning, one who treats and prescribes. I reside in Pennsylvania and am not impressed by my local psychiatrists! I would love to find one who specializes in Bipolar. I'm not holding my breath! I've researched on my end and am discouraged with the results. Any suggestions would be appreciated! Any thoughts on Lithium are also welcomed. Very aware of the potential SE of this and other mood stablizers. Unfortunately, these SE are what kept me from trialing medications for bipolar Dx. (Wt gain, cognitive impairment, etc) Thanks!
Answer This
Answers (1)
5/18/09 1:01am

Gatsby,

 

With medications you must weigh the pros and the cons.  The greatest negative is the result or impact of not being stable.  The second thing that needs to some consideration is the damage mood swings do to the brain.  Maybe you have heard about the lesions identified in the brains of individuals with bipolar disorder.  These are not due to medication they are the result of neuronal death, due to the effects of mood swings.

 

Now about the cursed lithium you have shyed away from.  First, I believe you know that all of the other choices for a mood stabilizer are antiepileptic drugs.  Of all of the mood stabilizers, lithium is is in the middle range for cognitive effects.  Lithium is also a neuroprotectant by increasing brain derived neurotrophic factor (BDNF).  I believe there are two of the the AED's that may also provide some neuroprotection.  Lithum has been studied the most, due to its long term use for mood disorder.  Lithium also has some effect on depression, making it a true mood stabilizer.  Better results have been seen when lithium is used along with an antidepressant in the treatment of depressive episodes.

 

Some people tolerate lithium well and have few side effects.  When a person begins a medication certain side effects are noticed and diminsh with time.  There are potential side effects that are monitored by blood tests, tested for at the same time lithium levels are tested.  I cannot give you any statistics on these but some people present with a decrease in thyroid hormone, so TSH, and T4 levels are monitored and the creatinine level is tested to monitor kidney function.  Kidney function is monitored because of the possible risk of developing diabetes insipidus.  This disorder results in the increase of water being removed from the body and more often than not reverses itself after lithium is discontinued.  These are not common side effects, tough they are monitored by psychiatrists due to the potential negative effects.

 

There is nothing wrong with the "gold standard" it has helped many lead more rewarding and productive lives.  I have taken it for more than two decades.  There is an artcle on this site regarding the action of lithium and if you follow the link there are a few more related articles you may read.

 

Another interesting feature to taking lithium is that researchers have found increases in gray matter, in the areas of the brain that control emotion.  There is much not known about the action of psychotropic medications but lithium is one of the best studied, known, and tested medications.

Reply
Answer This

Important:
We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

Ask a Question

Get answers from our experts and community members.

Btn_ask_question_med
View all questions (2514) >
By Gatsby— Last Modified: 09/01/10, First Published: 05/17/09